解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Event-related brain potentials were examined in 6 to 8-year-old children with primary language disorder before and after a 5-week narrative-based language intervention. Participants listened to sentences ending with semantically congruous or incongruous words. By comparison with typical controls, the children with pri...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832e9c97
更新日期:2009-08-05 00:00:00
abstract::In an earlier study, we reported the antinociceptive effects of a special repetitive transcranial magnetic stimulation paradigm: continuous theta-burst stimulation (cTBS), when applied to human motor cortex. Here, we investigated whether the reduced subjective pain perception of 10 healthy individuals could be measure...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832e0c74
更新日期:2009-08-05 00:00:00
abstract::Various clinical populations display atypical volume asymmetry of language structures and also the auditory M100 source. Although such atypical volume asymmetries have also been observed in autism, M100 source asymmetries have not yet been investigated. We examined M100 asymmetry in autism and its relationship with la...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832e0ca7
更新日期:2009-07-15 00:00:00
abstract::Dichotic pitches and mistuned harmonics can each lead to the perception of one or two auditory objects. Comparison of event-related potentials for the perception of one versus two objects reveals an early negative and a late positive component. The relationship of these components with auditory segregation was further...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832c92bf
更新日期:2009-07-01 00:00:00
abstract::To observe sequential stages in tactile pattern discrimination and their modification with and without attention, we used whole-head anatomically constrained magnetoencephalography to spatiotemporally map brain responses. Eight, normal, right-handed participants discriminated between two patterns presented on the palm...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832c5f65
更新日期:2009-07-01 00:00:00
abstract::In this study, we examine through electrophysiological measures three alternative mechanisms underlying musical chord priming: psychoacoustic distance, common parent-key, and distance along the circle of fifths. In contrast with previous behavioral studies, we present complex tones which do not blur the melodic compon...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832bfcaf
更新日期:2009-06-17 00:00:00
abstract::The Stroop effect refers to an increase in response time observed when the word meaning and the stimulus hue do not match. In an incongruent condition, the word 'green' is presented in the color red, whereas in a congruent condition the word 'red' is presented in the color red. To determine at what level of processing...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832a0a10
更新日期:2009-05-06 00:00:00
abstract::Event-related brain potential studies show that negative feedback in guessing tasks elicits a medial frontal negativity. Most theory and experimentation concerning this feedback-related negativity (FRN) has assumed that the FRN has little relationship to the perceptual characteristics of the feedback. This study chall...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832a3250
更新日期:2009-04-22 00:00:00
abstract::It has been reported that neurons in the amygdala respond to visual cues that predict reward and aversive outcomes. However, it remains unclear whether the representation of reinforcement in the amygdala depends on the relative preference for an outcome compared with another simultaneously available outcome. In this s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283294a2f
更新日期:2009-04-22 00:00:00
abstract::We used positron emission tomography to investigate whether tactile motion discrimination activates the dorsal visual stream in congenitally blind (CB) participants compared with sighted controls. The tactile stimuli consisted of either static dots, dots moving coherently in one of two possible directions, or in rando...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283279909
更新日期:2009-04-22 00:00:00
abstract::Thyroid hormone receptor beta2 (TRbeta2) controls the patterning of cone opsin photopigments that mediate colour vision. We raised an antiserum against TRbeta2 to study cone photoreceptor development by western blot and immunostaining analyses. TRbeta2-positive cells first appeared between embryonic day 10 (E10) and E...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832a2c63
更新日期:2009-04-22 00:00:00
abstract::Increasing evidence suggests that dynein has an important role in the clearance of misfolded proteins by autophagy. Here we show that treatment of cells with 1-methyl-4-phenylpyridinium (MPP) cause alpha-synuclein overexpression and aggregation, leading to the accumulation of autophagic vacuoles and the recruitment of...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832986c4
更新日期:2009-04-22 00:00:00
abstract::Neuromyelitis optica (NMO) is an inflammatory demyelinating disease of the central nervous system, and humoral immunity is suggested to play an important role in the pathogenesis. The identification of an anti-aquaporin-4 antibody (AQP4-Ab, neuromyelitis optica immunoglobulin G) in the sera of patients with NMO has le...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/wnr.0b013e32832776f4
更新日期:2009-03-25 00:00:00
abstract::We have recently characterized a form of ex vivo depotentiation (depotentiationex vivo), which correlates tightly with fear extinction, at thalamic input synapses onto the lateral amygdala. Here, we examined the effects of learning-attenuating drugs, reported to impair fear extinction when microinjected into the basol...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328329412d
更新日期:2009-03-25 00:00:00
abstract::We previously reported that clusterin enhances astrocyte proliferation and extracellular signal-regulated kinase (ERK) activity. It, however, remains largely unknown how clusterin promotes cell growth. Here, we investigate the signaling pathway and related molecules underlying astrocyte proliferation by clusterin. Exo...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283262df8
更新日期:2009-03-04 00:00:00
abstract::Frontolimbic structures involved in fear conditioning have also been associated with hypothalamic-pituitary-adrenal (HPA)-axis modulation, including amygdaloid, hippocampal, and ventromedial prefrontal cortex regions. Although HPA-axis function and endocrine changes have been investigated in the context of stress prov...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328326a031
更新日期:2009-03-04 00:00:00
abstract::The spatial-temporal expression and function of Drosophila melanogaster homothorax (hth) and its vertebrate homologue Meis2 in the eye anlage show a high degree of evolutionary conservation. Both are expressed by progenitor cells ahead of the neurogenic wave front, promote rapid proliferation of these cells, and are d...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32832000ae
更新日期:2009-02-18 00:00:00
abstract::Where and how the cortical areas are activated when a person receives the result of hypothesis testing is still unclear. By using a category induction task, this study provided participants with various batteries and asked them to learn which kind of batteries were charged. After learning, they were required to give a...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32831d7f6b
更新日期:2009-01-28 00:00:00
abstract::Emerging evidence has suggested that alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) protects neurons from glutamate-induced neurotoxicity. In this study, we examined the effect of AMPA on the cell surface expression of the N-methyl-D-aspartate (NMDA) receptor, a central player in glutamate-induced neurot...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283118450
更新日期:2009-01-28 00:00:00
abstract::Paraoxonase polymorphisms have been associated with amyotrophic lateral sclerosis (ALS). Paraoxonases are detoxifying enzymes involved in the metabolism of organophosphates. We tested the hypothesis that genetic variation within paraoxonase genes would interact with the environmental exposure to paraoxonase substrates...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32831af220
更新日期:2009-01-28 00:00:00
abstract::Humans are able to correct an ongoing movement very quickly in response to a suddenly moving target. Such fast responses possibly bypass the motor cortex and if so, one would expect that damage to the motor cortex would not greatly affect them. A group of children with congenital spastic hemiplegia were asked to move ...
journal_title:Neuroreport
pub_type: 杂志文章,随机对照试验
doi:10.1097/WNR.0b013e32831b0323
更新日期:2009-01-07 00:00:00
abstract::This study was carried out based on the assumption that brain-derived neurotrophic factor (BDNF) may counterbalance the action of morphine in the brain. Morphine analgesic tolerance after daily administrations for six days was blocked by intracerebroventricular injection of anti-BDNF IgG on day 5, but not by administr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328314decb
更新日期:2009-01-07 00:00:00
abstract::In an earlier screening, we identified several genes for kinases that might control the extension of neurites. One of these genes encoded a leukocyte tyrosine kinase (LTK), which is a receptor tyrosine kinase whose ligands remain to be identified. To examine the possible role of this LTK in neurite outgrowth, we const...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e3283186bf8
更新日期:2008-11-19 00:00:00
abstract::By using high-resolution, conventional, and neuromelanin-sensitive magnetic resonance imaging techniques, we reviewed the normal anatomy of the nuclei consisting of monoamine neurons such as dopaminergic, noradrenergic, and serotoninergic neurons and noted the changes in these nuclei that occur in some degenerative an...
journal_title:Neuroreport
pub_type: 杂志文章,评审
doi:10.1097/WNR.0b013e328315a637
更新日期:2008-11-19 00:00:00
abstract::Insulin-like growth factor-1 (IGF-1) and erythropoietin (EPO) are induced in brain cells after brain ischemia and show synergistic neuroprotective effects. In LN215 astrocytoma cells, IGF-1 induced the activation of hypoxia-inducible factor-1, leading to increases in EPO mRNA levels and the secretion of EPO. Interesti...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32831743fb
更新日期:2008-11-19 00:00:00
abstract::ErbBs are a family of receptors involved in the trophic maintenance of Schwann cells. Little is known about their expression changes during peripheral nerve regeneration. The aim of this study was thus to investigate variations in ErbBs after end-to-end and end-to-side nerve regeneration in the rat median nerve model....
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32831313ef
更新日期:2008-10-29 00:00:00
abstract::Altered glutamate signaling is associated with Parkinson's disease. To study the involvement of the cystine/glutamate antiporter in the pathogenesis of Parkinson's disease, we developed new polyclonal antibodies recognizing xCT, the specific subunit of this antiporter. The striatal xCT protein expression level was inv...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328312181c
更新日期:2008-10-29 00:00:00
abstract::As manifestations of prion diseases include disturbances of hypothalamic and pituitary functions, we tested the hypothesis that the cellular prion protein (PrPC) has a role as modulator of the hypothalamic-pituitary-adrenal axis. The level of corticosterone and adrenocorticotropic hormone were compared in PrPC null (P...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32830f1e90
更新日期:2008-10-08 00:00:00
abstract::The time course of responses to repeated presentations of affective stimuli is well characterized in healthy individuals but remains to be characterized in patients with bipolar disorder. Using functional magnetic resonance imaging, we compared early-stage and late-stage brain activation during a two-block fearful fac...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/WNR.0b013e328310af58
更新日期:2008-10-08 00:00:00
abstract::The relation between neuronal activity in the superior parietal lobule with working memory capacity in an elderly population was investigated. Using functional magnetic resonance imaging we examined effects associated with the performance of a reading span test and individual differences in executive function and shor...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/WNR.0b013e32830e000f
更新日期:2008-09-17 00:00:00
abstract::Voltage-gated K+ channels (K(V)) regulate cell electrical properties, proliferation, migration, and death. Rotenone is a mitochondrial inhibitor, influencing activity of many channels that potentially participate in cell death processes, but its effect on K(V) channel in neurons remains unclear. This study used whole-...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32830d149e
更新日期:2008-09-17 00:00:00
abstract::The amino acid glycine is an inhibitory neurotransmitter in the spinal cord, brain stem, and vertebrate retina. The effective synaptic concentrations of glycine are regulated by at least two transporters: glycine transporter 1 and glycine transporter 2. Here, we show retinal expression of glycine transporter 1 by in-s...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32830a9618
更新日期:2008-08-27 00:00:00
abstract::This study examined the relationship between social anxiety and the neural processing of threat in faces. Twenty-one adults with different levels of society anxiety were tested for their event-related potential responses to unattended threatening and nonthreatening faces, presented upright and upside-down, at three po...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/WNR.0b013e32830baadf
更新日期:2008-08-27 00:00:00
abstract::We earlier showed that leucine-rich glioma inactivated 3 (LGI3) colocalizes with amyloid beta peptide (Abeta) taken up by astrocytes both in vitro and in vivo, and that LGI3 accumulated with endocytosis-associated proteins in aged monkey brains. In this study, we confirmed that LGI3 localizes to the endocytic pathway ...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32830a4cc4
更新日期:2008-08-06 00:00:00
abstract::We report an event-related potential study investigating the neural basis of interference and facilitation in the picture-word interference paradigm with immediate overt naming. We used the high temporal resolution of the electrophysiological response to dissociate general and specific interference processes, by compa...
journal_title:Neuroreport
pub_type: 临床试验,杂志文章
doi:10.1097/WNR.0b013e328309ecd1
更新日期:2008-08-06 00:00:00
abstract::Recent studies have shown the nutrient-sensing systems transmitting nutritive information from the gut to the brain. However neural activity evoked by ingested dietary nutrients has not been investigated adequately. Using functional magnetic resonance imaging, we demonstrated that rat forebrain responded to intragastr...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328307c414
更新日期:2008-07-16 00:00:00
abstract::Aging and Alzheimer's disease (AD) are both characterized by memory impairments and sleep changes. We investigated the potential link between these disturbances, focusing on sleep spindles, involved in memory consolidation. Two episodic memory tasks were given to young and old healthy participants, as well as to AD pa...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e32830867c4
更新日期:2008-07-16 00:00:00
abstract::This study describes gamma-imaging of the secondary tumors from the transplanted human fetal striatum neural stem cells-derived primary tumor cells in nude mice. The subcutaneous primary tumors were detected to express integrin alphavbeta3, and the corresponding cells were isolated and enriched in vitro, then transpla...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328303c020
更新日期:2008-07-02 00:00:00
abstract::Hypoxia-inducible factor-1 (HIF-1) regulates the expression of neuroprotective genes such as erythropoietin (EPO). We investigated the mechanism by which zinc, an excitotoxin-like metal, regulates HIF-1 under hypoxic conditions in astrocytes. In hypoxic LN215 cells, HIF-1alpha stabilized and accumulated in the nucleus...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328304d9ac
更新日期:2008-07-02 00:00:00
abstract::This study aimed to investigate effects of observing the own body being touched on the functional topography of the somatosensory homunculus. We used neuromagnetic source imaging to map the topography in primary somatosensory cortex (SI) while manipulating the visibility of a touched hand. Participants were either abl...
journal_title:Neuroreport
pub_type: 杂志文章
doi:10.1097/WNR.0b013e328301a629
更新日期:2008-06-11 00:00:00